TABLE 2.
Summary of the effects of mutations in the PR on HIV-1 biological activitiesa
| Groupb | Mutation(s) in PR of gp41 | Viral infectivity (%) | Virion-cell fusion (%) | Cell-cell fusion (%) | gp120 association (%) | gp120 processing (%) |
|---|---|---|---|---|---|---|
| WT | None | 100 | 100 | 100 | 100 | 100 |
| M1 | S532P, T534A | 0 | 0.4 | 0 | 55 | 92 |
| M2 | T536A | 6.2 | 16.7 | 58.0 | 124 | 87 |
| M3 | S532P, T534A, T536A | 0.4 | 0.3 | 0 | 47 | 102 |
| M4 | S532P | 0.5 | 0.5 | 0 | 43 | 116 |
| M5 | T534A | 2.3 | 5.3 | 24.0 | 82 | 93 |
| M6 | S532A | 25.9 | 69.9 | 22.7 | ND | ND |
a
All percentages represent the average results of relative levels from at least 3 independent experiments. ND, not done.
b
WT, wild-type HIV-1NL4-3; M1 to M6, HIV-1NL4-3-derived PR mutations 1 to 6, respectively.