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Serial viral passage experiments with telaprevir against EV-D68
| Passage no. | Selection pressure (μM)a | EC50b (μM) | 2Apro mutation |
|---|---|---|---|
| 00 | 0.6 ± 0.1 | No mutation | |
| 01 | 0.5 | 1.1 ± 0.4 | NDc |
| 02 | 1 | ND | ND |
| 03 | 2 | 2.9 ± 0.2 | No mutation |
| 04 | 4 | ND | ND |
| 05 | 8 | >30 (resistant) | N84T |
US/KY/14-18953 (MOI, 0.1) was treated with telaprevirat the indicated concentrations.
EC50s were quantified using the CPE assay and are means ± SEs.
ND, not determined.
