FIG 10.

Correlations between antibody functions and epitope specificity in plasma IgG. (A) To determine if the functional activity of anti-HIV-1 antibodies in milk were associated with each other, correlations were tested between neutralization (HIVMW965) and phagocytosis (ConS gp140 beads, 1086.C beads, 92Th023 virions) for plasma IgG. Kendall’s tau values and corresponding corrected P values (see Materials and Methods) are reported. Boldface P values indicate significant correlations at a P value of <0.05, with corresponding absolute tau values color coded on a scale of 0 to 1. (B) To determine candidate antigen specificities that could be targeted for functional activity by plasma IgG antibodies, correlations were tested between antigen-specific binding and functional activity.