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Female resistance to low levels of CRF in the MS is not due to circulating ovarian hormones, but is linked to a sex difference in CRF-BP. A) OVX females responded similarly to the 3 ng dose of CRF as their sham-operated counterparts. The dashed line marks a ratio of 1, when an equal amount of time is spent with both objects, indicative of no memory. B) In the MS, females have more CRF-BP expression than males. Data are represented as mean ± SEM, asterisks indicate (p < .05).
