CRF1 expression and its ability to mediate the effect of CRF in the MS is similar in both sexes. A) Male and female rats have similar CRF1 expression in the MS. B) Pretreatment with the CRF1 antagonist, NBI 35965, blocked the effect of 100 ng of CRF in the MS in both sexes. The dashed line marks a ratio of 1, when an equal amount of time is spent with both objects, indicative of no memory. Data are represented as mean ± SEM, asterisk in legend indicates (p < .05) compared to other treatment groups.