Figure 2:

Physical characterization of PLGA-b-HA particles containing EGCG and MnO₂ nanocatalysts. (a) Transmission electron microscopic images of particles loaded with EGCG (a-i) and particles loaded with EGCG and MnO₂ nanocatalysts (a-ii). Red arrows indicate the existence of MnO₂ nanocatalysts. Scale bar = 50 nm. (b) Release profiles of EGCG over 24 h at 37 °C. EGCG-loaded particles with and without MnO₂ nanocatalysts were immersed in either phosphate-buffered saline (PBS) (i) or PBS containing 200 μM H₂O₂ (ii). (c) The rate of change of H₂O₂ concentration in media containing free MnO₂ nanocatalysts and particles with and without MnO₂ nanocatalysts. (d) The increase in pressure of O₂ gas (ΔP_O₂) at 24 h due to generation of O₂ from the decomposition of H₂O₂. The values and error bars represent the average values and standard deviation of three individual samples per condition, respectively. * represents the statistical significance of the difference of value for particles loaded with EGCG and MnO₂ nanocatalysts in PBS containing 200 μM H₂O₂ and that for each of the three other conditions. (* p < 0.05).