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. Author manuscript; available in PMC: 2019 Aug 11.
Published in final edited form as: Nat Chem Biol. 2019 Feb 11;15(4):419–426. doi: 10.1038/s41589-019-0229-2

Figure 1: HFNAP translation, selection, and library design.

Figure 1:

a, Overview of a complete cycle of HFNAP translation from DNA templates, selection for target affinity, reverse translation back to DNA templates, and template replication by PCR. b, Pool design showing how combinations of monomers are combined to make fully side-chain functionalized, partially functionalized, or unfunctionalized libraries. c, The seven sets of side-chain availability in each “genetic code” (top) and the 32 possible trinucleotide codons for each HFNAP.