Table 3.

Associations between genetic risk scores (GRSs) for ectopic fat and baseline and change in corresponding ectopic fat volumes in overall sample

	Model 1			Model 2
	Effect	SE	p-value	Effect	SE	p-value
VAT GRS (per standard deviation increase)
Baseline VAT, cm3	41	21	0.05	35	14	0.01
Change in VAT, cm3	−12	17	0.48	−12	17	0.49
SAT GRS (per standard deviation increase)
Baseline SAT, cm3	74	34	0.03	16	18	0.38
Change in SAT, cm3	6	18	0.73	5	18	0.80
VSR GRS (per standard deviation increase)
Baseline VSR	1.644	0.675	0.02	1.441	0.682	0.03
Change in VSR	−0.445	0.472	0.35	−0.282	0.472	0.55
PAT GRS (per standard deviation increase)
Baseline PAT, cm3	3.0	0.9	0.002	3.5	0.8	<0.001
Change in PAT, cm3	1.1	0.5	0.05	1.2	0.6	0.03

For the analyses of association between GRSs and baseline ectopic fat volumes, Model 1 adjusted for sex, age, and smoking status and Model 2 additionally adjusted for BMI GRS, WHR GRS, and baseline smoking status, physical activity, energy intake, MDS, and BMI; For the analyses of GRSs and association between change in ectopic fat depot volumes, Model 1 adjusted for sex, age, smoking status, and baseline ectopic fat volume and Model 2 additionally adjusted for BMI GRS, WHR GRS, baseline BMI, and change in smoking status, physical activity, energy intake, and MDS. VAT=Visceral Adipose

Tissue; SAT= Abdominal Subcutaneous Adipose Tissue; VSR=VAT to SAT Ratio; PAT=Pericardial Adipose Tissue; GRS=Genetic Risk Score; MDS=Mediterranean-style Diet Score; BMI=Body Mass Index; WHR=Waist to Hip Ratio; SE=Standard Error