Table 3.
Statistical models evaluating the association between anti-RNPC3 positive systemic sclerosis patients and the presence of moderate to severe GI disease in the confirmatory study (University of Pittsburgh Scleroderma Center cohort)
| Unadjusted Conditional Logistic Model 1 |
Adjusted1 Conditional Logistic for Age and Race Model 2 |
Adjusted2 Conditional Logistic for significant covariates Model 3 |
||||
|---|---|---|---|---|---|---|
| Characteristic | Odds Ratio | 95% Confidence Interval | Odds Ratio | 95% Confidence Interval | Odds Ratio | 95% Confidence Interval |
| Significant GI dysfunction | ||||||
| Medsger GI score <2 | 1.00 | 1.00 | 1.00 | |||
| Medsger GI score ≥2 | 3.84 | 1.50 – 9.83 | 3.79 | 1.43 – 10.02 | 3.81 | 1.02 – 14.28 |
| Race | ||||||
| Non-African American | 1.00 | 1.00 | 1.00 | |||
| African American | 3.58 | 1.11 – 11.48 | 2.36 | 0.65 – 8.54 | 5.59 | 0.64 – 48.7 |
| Diffuse cutaneous disease | 1.61 | 0.80 – 3.25 | - | - | 1.90 | 0.75 – 4.78 |
| Interstitial lung disease (ILD) | 5.85 | 2.33 – 14.65 | - | - | 2.79 | 0.95 – 8.19 |
| Myopathy | 0.36 | 0.08 – 1.61 | - | - | 0.07 | 0.01 – 0.75 |
| Age at Visit 1 | 0.97 | 0.95 – 1.00 | 0.97 | 0.95 – 1.00 | 0.97 | 0.94 – 1.01 |
GI = gastrointestinal;
1.
Adjusted conditional logistic regression model, adjusted for age and race;
2.
Adjusted conditional logistic regression model, adjusted for age and race, ILD, Diffuse cutaneous disease, Myopathy. Those covariates were selected by backwards selection.