Table 3.
Common bacterial taxa associated with colorectal cancer risk a
| Taxa | Median relative abundance |
OR (95% CI) b | P value b | P value c | |
|---|---|---|---|---|---|
| Cases (N=231) | Controls (N=461) | ||||
| Phylum Actinobacteria | |||||
| Family Bifidobacteriaceae | 0.09% | 0.05% | 1.10 (1.01–1.19) | 0.03 | 1.00 |
| Phylum Bacteroidetes | |||||
| Species Prevotella denticola | 0.14% | 0.07% | 1.11 (1.02–1.20) | 0.02 | 1.00 |
| Species Prevotella melaninogenica | 2.03% | 2.12% | 0.91 (0.84–0.99) | 0.04 | 1.00 |
| Species Prevotella sp. oral taxon 300 | 0.04% | 0.02% | 1.13 (1.01–1.26) | 0.04 | 1.00 |
| Phylum Firmicutes | |||||
| Family Carnobacteriaceae | 1.22% | 1.39% | 0.85 (0.72–0.99) | 0.04 | 1.00 |
| Family Streptococcaceae | 33.45% | 36.23% | 0.73 (0.56–0.96) | 0.02 | 1.00 |
| Genus Streptococcus | 33.40% | 35.92% | 0.73 (0.55–0.96) | 0.02 | 1.00 |
| Species S. sp. oral taxon 058 | 16.66% | 18.59% | 0.79 (0.67–0.94) | 7.87×10−3 | 0.42 |
| Family Erysipelotrichaceae | 0.09% | 0.09% | 0.87 (0.76–0.99) | 0.04 | 1.00 |
| Genus Solobacterium | 0.07% | 0.07% | 0.87 (0.76–0.98) | 0.02 | 1.00 |
| Species S. moorei | 0.07% | 0.07% | 0.87 (0.77–0.99) | 0.03 | 1.00 |
a
Common taxa were defined as those with a median relative abundance of >0.01% among control subjects
b
For each sample, centered log-ratio transformation was used to normalize taxa counts at each taxonomic level after adding a pseudocount of 1. The associations of taxon abundance with CRC risk was evaluated using conditional logistic regression. Smoking pack-years and alcohol consumption status were adjusted in the models
c
Bonferroni-corrected P values, adjusted for 53 independent tests