. Author manuscript; available in PMC: 2020 Oct 1.

Published in final edited form as: Arthritis Care Res (Hoboken). 2019 Aug 19;71(10):1353–1359. doi: 10.1002/acr.23766

Table 3.

Relation of thrust to WOMAC knee pain in subsets of knees without and with baseline radiographic OA and without pain at baseline.

Subset	Varus Thrust Status	n/N^*	Adjusted^** Odds Ratio (95% C.I.)	p-Value
Odds of Worsening Total WOMAC Knee Pain
Knees without Baseline ROA (KL < 2)	Present	135/447	1.38 (1.05, 1.83)	0.02
Knees without Baseline ROA (KL < 2)	Absent	290/1171	1.00 (ref)
Knees with Baseline ROA (KL ≥ 2)	Present	171/420	1.31 (0.99, 1.75)	0.06
Knees with Baseline ROA (KL ≥ 2)	Absent	227/703	1.00 (ref)
Odds of Clinically-Important^† Worsening Total WOMAC Knee Pain
Knees without Baseline ROA (KL < 2)	Present	97/447	1.09 (0.81, 1.48)	0.57
Knees without Baseline ROA (KL < 2)	Absent	232/1171	1.00 (ref)
Knees with Baseline ROA (KL ≥ 2)	Present	137/420	1.26 (0.94, 1.69)	0.12
Knees with Baseline ROA (KL ≥ 2)	Absent	189/703	1.00 (ref)
*Odds of Incident* Total WOMAC Knee Pain**
Knees with Baseline WOMAC Scores of 0	Present	122/362	2.01 (1.47, 2.74)	<0.0001
Knees with Baseline WOMAC Scores of 0	Absent	217/877	1.00 (ref)

Number of knees with outcome/Total knees

^**

Adjusted for age, sex, race, BMI, clinic site, gait speed, and static HKA alignment

^†

Clinically Important Worsening is an increase of at least 2 in WOMAC score for knees with a baseline score of 0 or an increase of at least 20% for knees with WOMAC scores greater than 0 (16, 17).