Table 1.
Univariate analysis of response with clinical parameters and H-scores
| Non-Responder (N=29) | Responder (N=7) | p value | |
|---|---|---|---|
| HR Status | 0.0081 | ||
| Deficient | 11 (37.9%) | 7 (100%) | |
| BRCA1/2 Mutant | 9 | 6* | |
| HR-proficient | 18 (62.1%) | 0 (0%) | |
| 53BP1 H-score | 0.122 | ||
| median | 90 | 140 | |
| Q1, Q3 | 70, 110 | 80, 180 | |
| Ku80 H-score | 0.132 | ||
| median | 10 | 40 | |
| Q1, Q3 | 0, 40 | 25, 65 | |
| Ku70 H-score | 0.192 | ||
| median | 0 | 10 | |
| Q1, Q3 | 0, 10 | 5, 30 | |
| PARP1 H-score | 0.242 | ||
| median | 60 | 110 | |
| Q1, Q3 | 25, 105 | 70, 115 | |
| XRCC4 H-score | 0.292 | ||
| median | 30 | 5 | |
| Q1, Q3 | 7.5, 50 | 0, 30 | |
| DNA-PKCS H-score | 0.432 | ||
| median | 20 | 50 | |
| Q1, Q3 | 5, 55 | 20, 60 | |
| RAD51 H-score | 0.972 | ||
| median | 15 | 20 | |
| Q1, Q3 | 5, 40 | 7.5, 25 |
*
The 7th patient responded had an ovarian cancer harboring a RAD51C promoter methylation
1
Fisher’s exact test
2
Kruskal-Wallis rank sum test