Table 1.

Summary of predictions and results. Results that correspond with predictions are shown in bold, results that did not are italicized. We predicted that FAAH A (AA and AC vs CC) and CRFR1 SNP minor alleles (AA, TT, TT) would interact to predict low baseline cortisol and the lowest state anxiety scores. We predicted the CC FAAH genotype (increased FAAH activity) would have high baseline cortisol and high anxiety scores. Additionally, we predicted CRFR1 minor allele carriers would show low cortisol and low anxiety.

CRFR1 Minor SNP carriers (“protective”, decreased HPA activity)		CRFR1 non-minor SNP carriers (“more risky”, increased HPA activity)
FAAH AA/AC (High AEA)	FAAH CC (Low AEA)	FAAH AA/AC (High AEA)	FAAH CC (Low AEA)
Higher cortisol Lower anxiety	Lower cortisol Higher anxiety	Lower cortisol Higher anxiety	Higher cortisol Lower anxiety