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. 2019 Mar 22;2:109. doi: 10.1038/s42003-019-0352-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Expression of immune checkpoint genes in virus-positive and negative tumors. The comparison of the expressions of immune checkpoint genes PD-L1, PD-L2, PD-1, CD80, CD86, CTLA-4, Tim-3, LAG-3, and 4-1BB as well as T-cell CD4 and CD8 markers for a HPV-positive and virus-negative tumors in HNSC, b EBV-positive and virus-negative tumors in STAD, c HBV-positive and virus-negative tumors in liver hepatocellular carcinoma and d Cytomegalovirus-positive and virus-negative tumors in colon and rectum adenocarcinoma. The “*”, “**”, and “***” symbols indicate p-value in the regions [0.05, 0.01], (0.01,0.001], and <0.001, respectively