Table 3.

SECA results for TS symmetry endophenotype

Trait 1	Trait 2	p-value pleiotropy	CI pleiotropy	p-value concordance	CI concordance	Direction
TS	Intracranial volume	1	1–1	0.191	0.183–0.198	–
	Accumbens	0.304	0.296–0.314	0.263	0.255–0.272	–
	Amygdala	0.298	0.289–0.307	0.002**	0.001–0.003	–
	Caudate	0.304	0.295–0.313	0.017**	0.015–0.02	+
	Hippocampus	1	1–1	0.07*	0.065–0.075	+
	Pallidum	1	1–1	0.417	0.408–0.427	+
	Putamen	0.313	0.304–0.322	0.001***	0–0.001	+
	Thalamus	1	1–1	1	1–1	–

TS Tourette’s syndrome, CI confidence interval, Bonferroni corrected p-value = 0.05/48 = 1.042 × 10⁻³

*Trending significance (p < 0.1)

**Nominally significant (p < 0.05)

***Significant