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. 2019 Mar 22;10:1354. doi: 10.1038/s41467-019-08778-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Parathyroid hormone (PTH) elicits its bone anabolic effect in a TG-interacting factor 1 (Tgif1)-dependent manner. a Representative images of proximal tibiae of 12-week-old male mice with the genotypes Dmp1-Cre⁻;Tgif1^fl/fl and Dmp1-Cre^Tg;Tgif1^fl/fl after von Kossa staining and fluorescence double labeling to visualize bone formation (insets). Dmp1-Cre⁻;Tgif1^fl/fl and Dmp1-Cre^Tg;Tgif1^fl/fl mice were treated with PTH or vehicle (Veh) for 4 weeks. Scale bars indicate 1 mm (black) and 50 μm (white). b Histomorphometric analysis of the proximal tibiae of 12-week-old Dmp1-Cre⁻;Tgif1^fl/fl and Dmp1-Cre^Tg;Tgif1^fl/fl male mice after PTH or Veh treatment for 4 weeks (Dmp1-Cre⁻;Tgif1^fl/fl+Veh: N = 8, Dmp1-Cre⁻;Tgif1^fl/fl+PTH: N = 8, Dmp1-Cre^Tg;Tgif1^fl/fl+Veh: N = 8, Dmp1-Cre^Tg;Tgif1^fl/fl+PTH: N = 8). For abbreviations see the legend to Fig. 1. *p<0.05, **p<0.01, ***p<0.001 vs. Veh of the same genotype. Error bars represent the s.e.m. Statistical analysis was performed using analysis of variance (ANOVA) followed by Newman–Keuls post-hoc test