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. 2019 Mar 22;9:5029. doi: 10.1038/s41598-019-41326-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Enzyme activity studies of GOx in GOX-Pt-Porphyrin-Alginate hybrid microspheres in comparison to plain alginate microspheres. (b) Leaching profiles of Pt-Porphyrin from PLA nanoparticles and hybrid matrices in different solvents like water, SLS and Ethanol: water mixture. (c) % cell viability on exposure to nanoparticles and hybrid microparticles using L929 mouse fibroblast cell line with test groups as DMSO (1), PLA nanoparticles (2), PLGA nanoparticles (3), PEI-PLGA nanoparticles (4), Alginate microspheres (5), Pt-Porphyrin in DMSO (6), Pt-Porphyrin in PLA (7), Pt-Porphyrin in PLGA (8), Pt-Porphyrin in PEI-PLGA (9), Pt-Porphyrin based hybrid microspheres (10).