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. 2019 Mar 22;10:1341. doi: 10.1038/s41467-019-09280-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Spatial sequences recurred more frequently than nonspatial sequence motifs. a CDFs of repetition indices for spatial (significant SSI from Fig. 2b, c; black) and significant sequence motifs with low SSI (gray) in control animals for epoch types (RUN: n_control = 7 epochs; PRE: n_control = 7 epochs; POST: n_control = 9 epochs) as indicated. Each CDF is derived from one epoch. b Same as in (a) for MEC-lesioned animals (red: significant SSI, pink: nonsignificant SSI; RUN: n_lesion = 9 epochs; PRE: n_lesion = 5 epochs; POST: n_lesion = 8 epochs). c Difference of medians between high- and low-SSI CDFs from (a) and (b), p values above bar were obtained from ranksum test, RUN: r.s. = 90, PRE: r.s. = 48, POST: r.s. = 85; p values above group labels were obtained from a binomial test on the number of significant epochs (circles) for a chance level of 5%; RUN: 6 out of 8 epochs were significant in control animals, 2 out of 9 epochs were significant in MEC-lesioned animals; PRE: 2 out of 8 epochs were significant in control animals, 3 out of 5 epochs were significant in MEC-lesioned animals; POST: 8 out of 9 epochs were significant in control animals, 4 out of 8 epochs were significant in MEC-lesioned animals; colors as in (a) and (b). d Relative (Rel.) occurrence computed as the fraction of spatially significant sequences among all bursts (p value obtained from ranksum test, RUN: r.s. = 103, PRE: r.s. = 62, POST: r.s. = 119; colors as in (a) and (b). e Same as d for low-SSI motifs (RUN: r.s. = 94, PRE: r.s. = 67, POST: r.s. = 130)