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. 2019 Mar 22;10:1338. doi: 10.1038/s41467-019-09292-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Allele-specific binding (ASB) events identified in the enhanced crosslinking and immunoprecipitation (eCLIP) data of HepG2 and K562 cells. a Number of heterozygous single-nucleotide variants (SNVs) identified via whole-genome DNA sequencing or eCLIP. Those that are common to both methods are illustrated. b Percentage of ASB events among all testable SNVs in each read coverage bin. The average read coverage of each SNV in the two replicated eCLIP experiments is shown here. A minimum read coverage of 10 was required. c Number of ASB events identified for each RNA-binding protein (RBP) in HepG2 and K562 cells. Only RBPs with ≥50 ASB events are shown. The number of usable eCLIP-Seq reads (in millions (M)) is shown for each RBP. d Number of ASB SNVs associated with one or more than one RBPs. e The overlap of ASB SNVs between HepG2 and K562. Only heterozygous SNVs common to the two cell lines are included. P value was calculated by Fisher’s exact test. (Source data are provided as a Source Data file)