Table 1.
Changes in blood variables after IV infusion of DS and MSS. DS, 5% dextrose solution (2 mL/kg BW) and MSS, MgSO4 50% solution (40 mg/kg BW) in 5% dextrose
| Treatments | ||||
|---|---|---|---|---|
| DS | MSS | |||
| Blood variable | Mean | SD | Mean | SD |
| pH (ref 7.35 to 7.45) | ||||
| 0 | 7.375 | ±0.021 | 7.390 | ±0.017 |
| 5 | 7.402 | ±0.015 | 7.393 | ±0.014 |
| 15 | 7.388 | ±0.015 | 7.395 | ±0.007 |
| 30 | 7.403 | ±0.022 | 7.400 | ±0.023 |
| 60 | 7.425 | ±0.014 | 7.397 | ±0.013 |
| 120 | 7.413 | ±0.021 | 7.397 | ±0.006 |
| SBE mmol/L (ref −3.0 to +3.0) | ||||
| 0 | 6.1 | ±1.2 | 6.5 | ±1.5 |
| 5 | 5.7 | ±1.4 | 5.6 | ±1.1 |
| 15 | 6.0 | ±1.2 | 6.3 | ±0.8 |
| 30 | 6.5 | ±1.5 | 6.7 | ±1.3 |
| 60 | 7.1 | ±1.9 | 6.0 | ±1.2 |
| 120 | 6.5 | ±1.5 | 6.0 | ±1.2 |
| HCO3 − mmol/L (ref 25 to 32) | ||||
| 0 | 31.1 | ±1.3 | 31.4 | ±1.5 |
| 5 | 30.4 | ±1.4 | 30.4 | ±1.2 |
| 15 | 30.9 | ±1.1 | 31.1 | ±0.9 |
| 30 | 31.3 | ±1.5 | 31.5 | ±1.4 |
| 60 | 31.5 | ±2.1 | 30.7 | ±1.2 |
| 120 | 31.1 | ±1.6 | 30.7 | ±1.4 |
| Na+ mmol/L (ref 135 to 145) | ||||
| 0 | 138 | ±2.2 | 134 | ±3.4 |
| 5 | 134 | ±1.8 | 131 | ±2.3 |
| 15 | 135 | ±1.8 | 132 | ±2.4 |
| 30 | 136 | ±1.9 | 133 | ±2.2 |
| 60 | 136 | ±1.6 | 133 | ±1.9 |
| 120 | 136 | ±2.4 | 132 | ±1.5 |
| Cl− mmol/L (ref 94 to 102) | ||||
| 0 | 103 | ±1.7 | 103 | ±1.9 |
| 5 | 101 | ±1.6 | 101 | ±1.1 |
| 15 | 102 | ±1.8 | 101 | ±2.0 |
| 30 | 103 | ±2.2 | 101 | ±2.0 |
| 60 | 103 | ±2.4 | 101 | ±1.9 |
| 120 | 102 | ±2.7 | 101 | ±1.9 |
| K+ mmol/L (3.3 to 5.0) | ||||
| 0 | 4.4 | ±0.8 | 4.3 | ±1.0 |
| 5 | 4.9 | ±0.7 | 4.3 | ±0.5 |
| 15 | 4.8 | ±0.8 | 4.2 | ±0.5 |
| 30 | 5.0 | ±0.7 | 4.2 | ±0.3 |
| 60 | 4.8 | ±0.5 | 4.0 | ±0.5 |
| 120 | 4.3 | ±0.6 | 3.8 | ±0.4 |
| Glucose mg/dL (ref 77 to 110) | ||||
| 0 | 91 | ±8 | 96 | ±7 |
| 5 | 156 | ±15 | 152 | ±9 |
| 15 | 134 | ±16 | 133 | ±9 |
| 30 | 98 | ±16 | 103 | ±15 |
| 60 | 89 | ±4 | 89 | ±8 |
| 120 | 92 | ±6 | 89 | ±6 |
| Lactate mmol/L (ref < 2) | ||||
| 0 | 0.8 | ±0.1 | 0.9 | ±0.5 |
| 5 | 1.0 | ±0.2 | 0.8 | ±0.2 |
| 15 | 1.1 | ±0.3 | 0.7 | ±0.1 |
| 30 | 0.9 | ±0.2 | 0.8 | ±0.2 |
| 60 | 0.9 | ±0.3 | 0.6 | ±0.2 |
| 120 | 1.1 | ±0.6 | 0.7 | ±0.2 |
| Ca2+ mmol/L (ref 1.40 to 1.60) | ||||
| 0 | 1.60 | ±0.05 | 1.52 | ±0.05 |
| 5 | 1.59 | ±0.04 | 1.44 | ±0.05 |
| 15 | 1.57 | ±0.05 | 1.39 | ±0.05 |
| 30 | 1.54 | ±0.03 | 1.38 | ±0.06 |
| 60 | 1.55 | ±0.05 | 1.40 | ±0.05 |
| 120 | 1.57 | ±0.07 | 1.44 | ±0.03 |
| tMg mg/dL (ref 1.9 to 3.0) | ||||
| 0 | 2.2 | ±0.2 | 2.0 | ±0.2 |
| 5 | 2.1 | ±0.1 | 4.5 | ±0.5 |
| 15 | 2.1 | ±0.1 | 3.9 | ±0.3 |
| 30 | 2.1 | ±0.2 | 3.4 | ±0.3 |
| 60 | 2.1 | ±0.1 | 3.0 | ±0.2 |
| 120 | 2.1 | ±0.2 | 2.5 | ±0.3 |
| Mg2+ mmol/L (ref 0.47 to 0.70) | ||||
| 0 | 0.51 | ±0.09 | 0.42 | ±0.05 |
| 5 | 0.50 | ±0.09 | 0.99 | ±0.10 |
| 15 | 0.49 | ±0.10 | 0.86 | ±0.09 |
| 30 | 0.48 | ±0.09 | 0.74 | ±0.09 |
| 60 | 0.47 | ±0.08 | 0.63 | ±0.06 |
| 120 | 0.50 | ±0.07 | 0.54 | ±0.04 |
Numbers in bold for the following variables, Na+, Cl−, K+, glucose, Ca2+, tMg, and Mg2+, indicate values above or below the reference range. Note: For SBE, the baseline values for all horses were above the reference range. Bold indicates difference from baseline values.
Abbreviations: DS, dextrose solution group; MSS, MgSO4 solution group; SBE, standard base excess; tMg, total magnesium.