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. 2019 Feb 4;29(4):1736–1751. doi: 10.1093/cercor/bhy341

Figure 2.

Figure 2.

TANK is required to establish normal alcohol drinking in mice. tank KO (n = 11) and wild-type (WT; n = 12) mice were tested in a free-choice 2-bottle drinking paradigm for their alcohol consumption. (a) Amount of alcohol consumed at different concentrations of the drinking fluid. (b) Preference of alcohol versus water. (c) Total fluid consumption during testing (pre-planned Bonferroni-corrected LSD test; *P < 0.05, **P < 0.01; vs. WT). (d) Consumption of 16 vol.% alcohol after 2 weeks of drinking and alcohol deprivation effect (ADE) in tank KO (n = 11) and WT (n = 12) mice. After continuous drinking, animals were withdrawn from alcohol for 2 times 3 weeks (dotted lines) and reinstated (R) for 4 days, respectively, (e) alcohol preference and (f) total fluid consumption during ADE (pre-planned Bonferroni-corrected LSD test; *P < 0.05, **P < 0.01; ***P < 0.001 vs. baseline (Bl)).