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. 2019 Feb 4;29(4):1736–1751. doi: 10.1093/cercor/bhy341

Figure 3.

Figure 3.

TANK controls preference for sweet taste in a 2-bottle free-choice paradigm in tank KO (n = 11) and wild-type (WT; n = 12) mice. (a) Sucrose (sweet) preference and quinine (bitter) avoidance test in a free-choice 2-bottle drinking paradigm indicates no difference between tank KO (n = 11) and WT mice (n = 12) in the avoidance of bitter tasting quinine, but a reduced preference for sucrose (pre-planned Bonferroni-corrected LSD test; ##P < 0.01). (b) A saccharine preference test in a free-choice 2-bottle drinking paradigm indicates a reduced preference for sweet tasting, but caloric neutral saccharin in naïve tank KO mice (n = 12) versus WT (n = 12) (pre-planned Bonferroni-corrected LSD test; #P < 0.05). (c) TANK has no effect on alcohol bioavailability in mice. Blood alcohol concentration in tank KO (n = 10) and WT mice (n = 10) after alcohol injection (3.5 g/kg, i.p.). Over the 3-h tested, there was no difference in alcohol bioavailability between genotypes (P > 0.05).