Figure 5.

TANK controls anxiety-related behavior in mice. Tank KO mice display more anxiety-related behavior in a novel environment than wild-type (WT) mice. Enhanced anxiety in the elevated plus maze test (EPM) by tank KO (n = 12) vs. WT (n = 11) mice shown by (a) reduced time spent and (b) less distance moved on open arms (P < 0.05) and (c) less relative time in open arms. (d) No effect on depression-related behavior in the novelty-suppressed feeding test in tank KO mice. (e) In the open field (OF) test, tank KO mice (n = 12) spend less time in the anxiogenic center of the maze than WT mice (n = 11). (f) The number of OF center entries is reduced in tank KO mice. Locomotor activity of tank KO mice is reduced in (g) the center of the maze, but also (h) when total locomotion is considered (pre-planned Bonferroni-corrected LSD test; ^#P < 0.05; ^$P < 0.001 vs. WT).