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. 2019 Mar 19;11:199–219. doi: 10.2147/CEOR.S177343

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© 2019 Macaulay et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Improvement in median OS over respective trial comparators vs total treatment cost for breast cancer, colorectal cancer, melanoma, non-small cell lung cancer, and renal cell carcinoma based on reported Kaplan–Meier OS curves.

Note: Regression line represents average value given cost. Gray shaded area below line represents below average value given cost.

Abbreviations: 1L, first line; 2L, second line; 3L, third line; 5-FU, 5-fluorouracil; Afat, afatinib; Aflib, ziv-aflibercept; Axit, axitinib; Bev, bevacizumab; BSC, best supportive care; Cabo, cabozantinib; Cape, capecitabine; Cetux, cetuximab; Cobi, cobimetinib; Criz, crizotinib; Dabraf, dabrafenib; Doce, docetaxel; EGFR, epidermal growth factor receptor; Erib, eribulin; Erlot, erlotinib; Evero, everolimus; FOLFIRI, folinic acid, fluorouracil, irinotecan; FOLFOX, folinic acid, fluorouracil, oxaliplatin; Gefit, gefitinib; Ifo, ifosfamide; ILF, infusional 5-FU; Ipi, ipilimumab; ITT, intent-to-treat; KN, KEYNOTE; Lapat, lapatinib; Lenvat, lenvatinib; LV, leucovorin; M(c), maintenance (continuous); M(s), maintenance (switch); Nab-p, nab-paclitaxel; Neci, necitumumab; Nivo, nivolumab; NSQ, non-squamous; OS, overall survival; OxMdG, oxaliplatin/modified de Gramont chemotherapy; Panit, panitumumab; Pazop, pazopanib; Pembro, pembrolizumab; Pemet, pemetrexed; Pertuz, pertuzumab; Ph, phase; Ramu, ramucirumab; Regor, regorafenib; Soraf, sorafenib; SQ, squamous; Sunit, sunitinib; Tems, temsirolimus; Tipi, tipiracil; Tramet, trametinib; Trastuz, trastuzumab; Triflu, trifluridine; Vem, vemurafenib; Vin, vinorelbine; WT, wild type; XELOX, capecitabine + oxaliplatin.