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. 2019 Mar 19;11:199–219. doi: 10.2147/CEOR.S177343

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© 2019 Macaulay et al. This work is published and licensed by Dove Medical Press Limited

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Improvement in mean OS over respective trial comparators vs total treatment cost for melanoma, non-small cell lung cancer, and renal cell carcinoma based on fitted Kaplan–Meier OS curves that extrapolate survival beyond the reported cutoffs. Regression line represents average value given cost. Gray shaded area below line represents below average value given cost.

Abbreviations: 1L, first line; 2L, second line; 3L, third line; Bev, bevacizumab; Cabo, cabozantinib; Criz, crizotinib; Dabraf, dabrafanib; Doce, docetaxel; EGFR, epidermal growth factor receptor; Erlot, erlotinib; Evero, everolimus; Gefit, gefitinib; Ifo, ifosfamide; Ipi, ipilimumab; ITT, intent-to-treat; Lenvat, lenvatinib; M(c), maintenance (continuous); M(s), maintenance (switch); Nab-p, nab-paclitaxel; Nivo, nivolumab; NSQ, nonsquamous; OS, overall survival; Pazop, pazopanib; Pembro, pembrolizumab; Pemet, pemetrexed; Ph, phase; Ramu, ramucirumab; Soraf, sorafenib; SQ, squamous; Sunit, sunitinib; Tems, temsirolimus; Tramet, trametinib; Vem, vemurafenib; Vin, vinorelbine; WT, wild type.