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. 2019 Mar 22;17:97. doi: 10.1186/s12967-019-1849-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Dissolution kinetics of OZ439 when unencapsulated (green triangles) or encapsulated into nanoparticles via FNP and processed into a dry powder by lyophilization (blue diamonds) or spray drying (red squares). Spray dried NPs achieved up to 20-fold superior OZ439 solubilization compared to OZ439 mesylate powder in FaSSIF, and also outpaced lyophilized NPs by up to 1.3 times