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. 2019 Mar 22;17:97. doi: 10.1186/s12967-019-1849-8

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — Dissolution kinetics of lyophilized OZ439 NP powder after storage in an oven at 50 °C and 75% RH in uncapped vials. Though the powder’s appearance changed radically after 1 day in the oven (see Additional file 1: Figure S1), the dissolution kinetics of encapsulated OZ439 remained largely the same over the course of a week in these conditions. After 1 day (red squares) and 7 days (green triangles) in the oven, OZ439 dissolution kinetic profiles matched those of the powder immediately after lyophilization, both in terms of completeness and shape. In all cases, 60–70% of OZ439 was solubilized, with NPs FeSSIF reaching this plateau faster than NPs in FaSSIF