Table 2.
Age-stratified unadjusted relative (rate ratio) and absolute (rate difference) comparisons of rates of health services encounters in MCAD deficiency cohort versus screen negative cohort
| Outcome and age group | Incidence rate ratio (IRR), MCAD deficiency cohort vs. screen negative cohort (95% CI) | Incidence rate difference (IRD), MCAD deficiency cohort vs. screen negative cohort, per child per year (95% CI) |
|---|---|---|
| Physician encounters | ||
| < 6 months | 1.2 (1.1, 1.3) | 4.2 (2.1, 6.4) |
| 6 to < 12 months | 1.6 (1.4, 1.8) | 5.8 (4.1, 7.5) |
| 12 to < 18 months | 1.3 (1.1, 1.5) | 2.9 (1.3, 4.5) |
| 18 to < 24 months | 1.7 (1.5, 1.9) | 5.0 (3.4, 6.6) |
| 2 to < 3 years | 1.4 (1.2, 1.5) | 2.0 (1.1, 2.9) |
| 3 to < 4 years | 1.5 (1.3, 1.7) | 2.4 (1.3, 3.4) |
| ≥ 4 years | 1.5 (1.3, 1.7) | 2.5 (1.4, 3.6) |
| Emergency department visits | ||
| < 6 months | 1.9 (1.3, 2.7) | 0.7 (0.2, 1.2) |
| 6 to < 12 months | 3.1 (2.4, 4.1) | 1.7 (1.0, 2.4) |
| 12 to < 18 months | 2.6 (2.0, 3.5) | 1.4 (0.8, 2.1) |
| 18 to < 24 months | 2.7 (2.0, 3.7) | 1.3 (0.7, 2.0) |
| 2 to < 3 years | 2.1 (1.6, 2.9) | 0.7 (0.3, 1.1) |
| 3 to < 4 years | 2.0 (1.4, 3.0) | 0.5 (0.1, 0.9) |
| ≥ 4 years | 1.7 (1.1, 2.6) | 0.3 (−0.03, 0.7)a |
| Inpatient hospitalizations | ||
| < 6 months | 1.6 (0.8, 3.5)a | 0.1 (− 0.1, 0.4)a |
| 6 to < 12 months | 10.8 (6.1, 18.9) | 0.5 (0.2, 0.9) |
| 12 to < 24 months | 9.6 (6.1, 15.0) | 0.4 (0.2, 0.6) |
| 2 to < 3 years | 10.8 (6.3, 18.7) | 0.3 (0.1, 0.5) |
| ≥ 3 years | 15.2 (9.7, 23.8) | 0.4 (0.2, 0.5) |
aDifference not statistically significant, p > 0.05; all other rates were statistically significantly different between the two cohorts