Table 4.
Analyses of MFR and ESVI
| Myocardial flow reserve | ||||
|---|---|---|---|---|
| Univariable | Multivariable | |||
| Percent change per unita (95% CI) | P-value | Percent change per unit a (95% CI) | P-value | |
| End-systolic volume/BSA (10 ml/m2) | − 3.7 (− 5.6; − 1.8) | < 0.001 | −4.5 (− 7.9; − 0.9) | 0.02 |
| Male sex | −8.5 (− 20.0; 4.6) | 0.19 | 3.9 (− 10.4; 20.5) | 0.60 |
| Age (10y) | − 8.0 (− 13.5; − 2.1) | < 0.01 | −1.6 (− 8.7; 6.2) | 0.68 |
| Hypertension | 0.8 (− 12.0; 15.4) | 0.91 | 3.9 (− 9.4; 19.2) | 0.58 |
| Type 2 diabetes | −11.1 (− 24.3; 4.5) | 0.15 | −1.0 (− 16.1; 16.7) | 0.90 |
| Log2(NT-pro-BNP) | −3.8 (− 8.1; 0.7) | 0.10 | 1.7 (− 3.6; 7.3) | 0.54 |
| Left ventricular bundle branch block | 1.2 (− 11.3; 15.5) | 0.85 | 5.7 (− 18.4; 9.1) | 0.43 |
| LVEF at rest (10%) | 6.1 (1.9; 10.5) | < 0.01 | − 4.5 (− 11.9; 3.5) | 0.26 |
| Atrial fibrillation during scan | −27.6 (− 37.7; − 16.0) | < 0.0001 | −26.1 (− 38.4; − 11.4) | < 0.01 |
| Increases in heart rate from rest to stress | 1.0 (0.4; 1.5) | < 0.001 | 0.8 (0.0; 1.6) | 0.049 |
| CACS (100 units) | −1.6 (− 2.7; − 0.5) | < 0.01 | −1.5 (− 2.6; − 0.3) | 0.01 |
aEstimated differences are expressed in relative terms, i.e. as a percentage. CI confidence interval, BSA body surface area. LVEF Left ventricular ejection fraction. CACS Coronary calcium score