Carotid artery catheters were implanted in WT (gray line), Tg1 (black dashed line), and Tg2 (black solid line) mice. The following day, the mice received E. coli LPS (10 mg/kg) IP. Mean arterial pressure (MAP) was measured at 2, 4, 6, 8, and 24 hours after injection of LPS. Data points represent mean MAPs ± SEM, for WT (n=10), Tg1 (n=8), and Tg2 (n=11) mice. Data was assessed by two-way ANOVA (P<0.0001). Significant comparison, * versus WT mice.