TABLE 4.
NDM inhibitors reported
| Inhibitor(s) | Description | Reference(s) |
|---|---|---|
| Sulfur-containing inhibitors | ||
| Bisthiazolidines | Penicillin analogs containing thiol | 404 |
| Captopril and various analogs | Angiotensin-converting enzyme inhibitor | 405, 406 |
| Thiorphan | Active metabolite of racecadotril, a peripherally acting enkephalinase inhibitor | 407 |
| Thiophenecarboxylic acid derivatives | Sulfur atom of the thiophene ring | 408 |
| Thioazoles and thiophene-containing amino acid thioesters | 409, 410 | |
| Tryptophan-containing compound | Thiol-containing amides | 411 |
| Sulfonamides | 412 | |
| Thiol-containing compounds | 413 | |
| ANT431 | Pyridine-2-carboxylic acid derivative | 304 |
| Metal-complexing agents | ||
| 1,4,7-Triazacyclononane-1,4,7-triacetic acid | Metal chelators | 414 |
| 1,4,7,10-Tetraazacyclononane-1,4,7,10-tetraacetic acid | Metal chelators | 414 |
| Calcium disodium EDTA | Metal chelators | 306, 415, 416 |
| ME1071 (disodium 2,3-diethylmaleate) | Maleic acid derivative | 287 |
| Colloidal bismuth subcitrate and related Bi(III) compounds | Anti-Helicobacter pylori drug | 417 |
| Inhibitor 36 | 2,6-Dipicolinic acid derivative | 418 |
| Aspergillomarasmine A | Extract of a strain of the fungus Aspergillus versicolor | 305 |
| Chromenes | ||
| Chromenone compound | 419 | |
| Chromenone and chromeno[3,2-c]pyridine compound | 2 polyketides isolated from Penicillium sp. from the rhizosphere soil of the plant Picea asperata | 420 |
| 3-Formylchromone | 421 | |
| 3-Cyanochromone | 421 | |
| Thiol-modifying agents | ||
| p-Chloromer-curibenzoic acid and sodium nitroprusside [Na2Fe(CN)5NO·2H2O] | Thiol-modifying agents | 422 |
| Ebselen | Selenium-containing molecule | 423 |
| Covalent irreversible inhibition by β-lactams | ||
| Supratherapeutic doses of β-lactams such as cephalothin and moxalactam | Key residue for interaction with the substrate | 424 |
| β-Phospholactam | Tetrahedral transition state analog | 425 |
| 4-Chloroisoquinolinols | 426 | |
| Aminoimidazoles | 427 | |
| Synthetic nucleotide analogs | ||
| Peptide-conjugated phosphorodiamidate morpholino oligomer | 428 | |