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. Author manuscript; available in PMC: 2019 Aug 31.
Published in final edited form as: Sci Immunol. 2018 Aug 31;3(26):eaat7668. doi: 10.1126/sciimmunol.aat7668

Fig. 4. NK receptors on T-CTLs are functional and may modulate TCR-induced release of cytotoxic granules.

Fig. 4.

T-CTLs were enriched from other subsets by cell sorting for either NKG2A (A+) or NKG2C (C+). (A) Each population was stimulated with anti-CD94 or left in medium for 20 hours. GZMB, PRF, and GNLY release was measured in the culture supernatants by ELISA. The log % change of the anti-CD94 stimulation relative to medium is shown. (B) Each population was stimulated with anti-CD3 or anti-CD3 and anti-CD94 for 20 hours, and cytotoxic granule proteins were measured by ELISA. The log % change of the anti-CD94 plus anti-CD3 relative to anti-CD3 alone is shown. *P < 0.05, **P < 0.01, ***P < 0.001.