Fig.

1.—(A–D) Graphical representations of all modular PKS (mPKS) genes, Red indicates genes in a syntenic location downstream of each of the larger mPKS genes (shown in blue). (E) Alignment of mPKSa and mPKSc enzymatic domains, highlighting comparative presence or absence of domains. (F) Alignment of mPKSb and mPKSd enzymatic domains, highlighting comparative presence or absence of domains. (Note: domain alignments are not based on phylogenetic relationship, but merely the order in which they occur). Domain abbreviations: ACP, acyl carrier protein; KS, ketoacyl synthase; DH, dehydratase; KR, ketoreductase; AT, ACP transacylase; ER, enoyl reductase; MT, methyltransferase; TH, thiohydrolase. KS and AT are each highlighted (red and blue, respectively) as they are discussed in greater detail in the text.