Table 1.
The pharmacokinetics of verticine in references.
| Models | Extracts/compounds | Methods | Mode of administration | Pharmacokinetic parameters | Ref. |
|---|---|---|---|---|---|
| Rabbits | Verticine | LC-MS/MS | ig administration iv administration |
A two-compartment model, Cmax= 48.31±7.40 ng/mL, AUC0∞= 270.08±80.17 ng/(mL/h), t1/2=6.38±3.11 h A three-compartment model, Cmax= 84.39±15.39 ng/mL, AUC0∞=50.72±14.02 ng/(mL/h), t1/2= 2.19±1.07 h |
[2] |
|
| |||||
| Sprague-Dawley female rats Sprague-Dawley male rats |
4.25 g/kg Fritillaria thunbergii Miq. Extract | LC-MS/MS | a single oral administration | Cmax= 43.7±22.7 ng/mL, Tmax=1.5±0.7h, t1/2=4.2±2.0 h, AUC0t= 214.2±84.6 ng/(mL/h), AUC0∞= 214.3±84.5 ng/(mL/h), CL/F= 128.9±32.6 L/kg/h, V/F= 781.3±305.6 L/kg Cmax= 57.6±21.6∗ ng/mL, Tmax=2.9±1.7∗ h, t1/2=6.2±1.9 h, AUC0t= 662.4±277.9∗ ng/(mL/h), AUC0∞= 665.3±213.3∗ ng/(mL/h), CL/F= 41.5±20.1 L/h/kg, V/F= 374.1±186.2 L/kg |
[3] |
|
| |||||
| Sprague-Dawley Rats | Fritillaria thunbergii Miq. Extract (0.45 g/kg body weight) | RRLC-MS/MS | gastric gavage | A two-compartment model, Cmax= 3.671±0.876 μg/L, Tmax=32.5±11.292 min, t1/2α= 29.269±24.156 min, t1/2β=162.897±30.669 min, AUC0t= 628.568±100.99 μg/(L∗ min), AUC0∞= 630.875±102.136 μg/(L∗ min), CL/F= 0.423±0.075 L/min/kg, V1/F= 40.832±17.616 L/kg | [4] |
∗ p<0.05, significantly different from female rats.