Table 3.
Univariate and multivariate analyses of prognostic factors for overall survival in CRC patients.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Gender | ||||||
| Male vs. female | 1.591 | 0.966-2.619 | 0.068 | NA | ||
| Age | ||||||
| ≤60 vs. >60 | 1.008 | 0.0.617-1.648 | 0.973 | NA | ||
| Tumor location | ||||||
| Right colon vs. left colon vs. rectum | 1.038 | 0.773-1.393 | 0.806 | NA | ||
| Differentiation | ||||||
| Poor vs. well and middle | 0.533 | 0.177-1.607 | 0.264 | NA | ||
| TNM stage | ||||||
| 0 and I vs. II vs. III vs. IV | 2.023 | 1.532-2.672 | <0.001∗ | 0.980 | 0.469-2.050 | 0.958 |
| T stage | ||||||
| Tis, T1, and T2 vs. T3 and T4b | 3.398 | 1.692-6.825 | 0.001∗ | 2.079 | 0.726-5.951 | 0.173 |
| N stage | ||||||
| N0 vs. N1a vs. N1b vs. N2a and N2b | 1.493 | 1.207-1.847 | <0.001∗ | 1.044 | 0.734-1.486 | 0.809 |
| M stage | ||||||
| M0 vs. M1 | 5.983 | 3.244-11.036 | <0.001∗ | 1.986 | 0.665-5.934 | 0.219 |
| Preoperative CEA (ng/ml) | ||||||
| ≤5 vs. >5 | 1.241 | 0.930-1.657 | 0.142 | NA | ||
| LTBP2 expression | ||||||
| Low and none vs. high | 23.619 | 13.036-42.794 | <0.001∗ | 21.056 | 11.274-39.326 | <0.001∗ |
Abbreviation: HR, hazard ratio; CI, confidence interval: NA, not considered in the multivariable model.