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. 2019 Mar 10;2019:2514956. doi: 10.1155/2019/2514956

Figure 3.

Figure 3

Relative expression of RANK-L/OPG and extent of hPDL fibroblast-mediated osteoclastogenesis. (a) RANK-L expression according to Western blot densitometry (N = 7), (b) sRANK-L and (c) OPG protein secretion according to ELISA (N = 2, n = 6), and (d, e) osteoclastogenesis after coculture with RAW264.7 cells (TRAP staining and mono- and multinucleated osteoclast precursor and osteoclast-like TRAP-positive cells in red, N = 2, n = 6), given as normalized x-fold induction relative to 0 μM etoricoxib without mechanical strain. Asterisms without bars indicate significant differences to the corresponding 0 μM control. Abbreviations: see manuscript text. ∗ p ≤ 0.05, ∗∗ p ≤ 0.01, and ∗∗∗ p ≤ 0.001. AU: arbitrary units. Bars show mean and standard deviation; TRAP: tartrate-resistant acid phosphatase.