Figure 4.
Relative expression of alkaline phosphatase (a, b) (bone formation), as well as of VEGF-A (c) (angiogenesis) and P4HA1, COL1A2, and FN1 (d), (e), and (f), respectively (extracellular matrix remodeling), except for ELISA as normalized x-fold induction relative to 0 μM etoricoxib without mechanical strain. Abbreviations: see manuscript text. ∗ p ≤ 0.05, ∗∗ p ≤ 0.01, and ∗∗∗ p ≤ 0.001. AU: arbitrary units. Bars show mean and standard deviation. ELISA: N = 2, n = 6; RT-qPCR: N = 3, n = 9; ELISA: enzyme-linked immunosorbent assay; RT-qPCR: real-time reverse transcription quantitative polymerase chain reaction.