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. 2019 Mar 7;2019:9496419. doi: 10.1155/2019/9496419

Figure 5.

Figure 5

The PI3K/AKT signaling pathway involved in the antiapoptotic effects of a nicotinic agonist in the CVB3-induced apoptosis of NRC. (a) The MTT assay assessing the cell viability of NRC treated with different concentrations of LY294002. ∗P < 0.05 and ∗∗P < 0.01 vs. the control group. (b-d) After being stimulated by CVB3 for 2 h, LY294002 was used to ablate nicotine-induced inhibition of pAkt and survivin expression for 1 h. 1 μM nicotine was then added to the culture for another 36 h. The expression of pAkt and survivin was measured by western blot. aP < 0.05 vs. the CVB3-infected group. bP < 0.05 vs. the nicotine-treated group.