Table 2.
The effect of cerulein AP on serum and plasma redox markers.
| C n = 9 |
AP n = 9 |
p | |
|---|---|---|---|
| Enzymatic and nonenzymatic antioxidants | |||
| SOD serum (mU/mg protein) | 4.457 ± 0.8291 | 2.814 ± 0.5526 | 0.1215 |
| CAT serum (nmol H2O2/min/mg protein) | 1.103 ± 0.1172 | 1.532 ± 0.1456 | 0.0375 |
| GPx serum (mU/mg protein) | 0.1063 ± 0.009871 | 0.07513 ± 0.005437 | 0.0150 |
| GR serum (uU/mg protein) | 30.48 ± 3.056 | 22.02 ± 0.6425 | 0.0169 |
| GSH plasma (ng/mg protein) | 2.316 ± 0.2375 | 1.54 ± 0.1185 | 0.0111 |
| Redox status | |||
| TAC plasma (Trolox μmol/mg protein) | 0.8814 ± 0.02703 | 0.6953 ± 0.01159 | <0.0001 |
| TOS plasma (nmol H2O2 Equiv/min/mg protein) | 3.757 ± 0.4319 | 4.79 ± 0.7327 | 0.2447 |
| OSI plasma | 4.315 ± 0.5528 | 6.895 ± 1.074 | 0.0508 |
| Free radical generation | |||
| NOX plasma (nmol O2−/min/mg protein) | 13.46 ± 0.47 | 17.75 ± 0.49 | <0.0001 |
| XO plasma (μU/mg protein) | 21.42 ± 0.75 | 28.77 ± 0.95 | <0.0001 |
| ROS production plasma (nmol/h/mg protein) | 10.12 ± 0.11 | 15.4 ± 0.18 | <0.0001 |
| Protein oxidative damage | |||
| AGE plasma (AFU/mg protein) | 5.227 ± 0.1993 | 6.197 ± 0.308 | 0.0192 |
| AOPP plasma (nmol/mg protein) | 2.799 ± 0.8918 | 23.98 ± 4.132 | 0.0002 |
C: controls; AP: acute pancreatitis; SOD: superoxide dismutase; CAT: catalase; GPx: glutathione peroxidase; GR: glutathione reductase; GSH: reduced glutathione; TAC: total antioxidant capacity; TOS: total oxidant status; OSI: oxidative status index; AGE: advanced glycation end products; AOPP: advanced oxidation protein products; NOX: NADPH oxidase; XO: xanthine oxidase; ROS: reactive oxygen species.