Table 6.
Effect of Adansonia digitales leaf extract on blood cell count, glycosylated hemoglobin, and erythropoietin of diabetic rats.
| Parameters | Groups | ||||
|---|---|---|---|---|---|
| Normal control | Diabetic control | Diabetic + Leaf extract | Diabetic + GBC 0.5 mg/Kg | ||
| 200 mg/kg | 400 mg/kg | ||||
| RBCs count (x106/ml) | 7.50±0.46 | 4.00 ±0.25N | 4.70±0.11N∗@ | 5.33±0.25N∗@ | 6.11 ±0.16N∗ |
|
| |||||
| WBCs count (x105/ml) | 5.40 ±0.23 | 12.50±0.65N | 9.76±0.47N∗@ | 8.00±0.41N∗ | 7.65±0.58N∗ |
|
| |||||
| Hb level (g/dl) | 16.00±1.04 | 11.85±0.49N | 12.50±0.23N∗@ | 14.78±0.54N∗ | 14.90±0.36N∗ |
|
| |||||
| PCV (%) | 50.00±2.96 | 35.19±1.28N | 44.00±2.18N∗@ | 53.39±3.21∗ | 54.00±3.25∗ |
|
| |||||
| GHb (%) | 4.56±0.07 | 13.00±0.48N | 8.60 ±0.54N∗@ | 7.00±0.16N∗ | 7.50±0.68N∗ |
|
| |||||
| EPO (ng/ml) | 2.78±0.04 | 0.58±0.01N | 1.34±0.05N∗@ | 1.86±0.03N∗@ | 2.20±0.06N∗ |
All the data has been expressed as mean ± SEM of eight independent samples from each group (n = 8) analyzed by SPSS 13.0 version. The treated groups are CN (control normal), DM (diabetic or group II). DM+E200: diabetic rats treated with 200mg/Kg of leaf extract (group III); DM+E400: diabetic rats treated with 400mg/Kg of leaf extract; DM+GBC (group IV): diabetic rats treated with glibenclamide (group V).
N: significant difference from normal control.
∗: significant difference from positive control (untreated diabetic).
@: significant difference from the reference drug, glibenclamide.
GBC: glibenclamide; GHb: glycosylated hemoglobin; EPO: Erythropoietin.