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. 2019 Mar 7;2019:1292891. doi: 10.1155/2019/1292891

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Copyright © 2019 Yihang Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TaClo impaired the nigrostriatal system. (a) Comparison of stereotaxic coordinates in an atlas of the rat brain and the ROI assessed using DTI. Arrows pointing from A to C and from B to C show the SNc and striatum, respectively. (b) Images of the general outline of the nigrostriatal system indicate the obvious destruction of this region in the TaClo-injected rats compared to the other two groups. (c) Histogram showing a significant increase in the ADC value for the nigrostriatal system after TaClo injection. ^∗ p < 0.05 compared to the control group. ^∗ p < 0.05 compared to the sham group. (d) The FA value for the NP did not significantly change. (e) LFB staining showing demyelination in the SNc of the TaClo-treated rats (arrow).