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. 2019 Mar 7;2019:1292891. doi: 10.1155/2019/1292891

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Copyright © 2019 Yihang Yang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

TaClo caused mitochondrial oxidative stress in the nigrostriatal system. (a) The expression of representative genes related to oxidative stress and inflammation from the GEO database (GSE7621-GPL570) was analysed. (b) ATP production was reduced after TaClo treatment. ^∗∗ p < 0.01 compared to the control group. (c and d) FCM revealed an apparent increase in the MFI of ROS in the TH-positive cells from the TaClo-treated group compared to the control group. (e and f) Results of JC-1 staining in the two groups. The ratio of green and red fluorescence was increased after the TaClo treatment. ^∗ p < 0.05 compared to the control group. Scale bar 100 μm.