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. 2019 Mar 18;10:472. doi: 10.3389/fimmu.2019.00472

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Copyright © 2019 Rocamora-Reverte, Tuzlak, von Raffay, Tisch, Fiegl, Drach, Reichardt, Villunger, Tischner and Wiegers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased frequency of antinuclear antibodies (ANA) in Foxp3-Cre GRfl/fl mice. (A) Flow cytometry analysis of splenic total CD4⁺ and CD4⁺Foxp3⁺ Treg cells (expressed as a percentage of total CD4⁺ cells) from Foxp3-Cre and Foxp3-Cre GRfl/fl mice. (B) Example of ANA determination by immunofluorescence. Mouse sera were incubated with HEp-2 cells and the presence of ANA was determined by indirect immunofluorescence microscopy. The sample on the left is ANA negative, while the sample on the right is considered ANA positive. (C) Presence of ANA in sera from 8 to 13 months old Foxp3-Cre and Foxp3-Cre GRfl/fl mice. Data are shown as mean ± SEM (n ≥ 7).