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. 2019 Mar 18;10:497. doi: 10.3389/fimmu.2019.00497

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Copyright © 2019 Łyszkiewicz, Kotlarz, Ziȩtara, Brandes, Diestelhorst, Glage, Hobeika, Reth, Huber, Krueger and Klein.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Aberrant expansion of LAMTOR2-deficient B cells in response to B-cell receptor stimulation. Splenic follicular B cells isolated from LAMTOR2^fl/fl or LAMTOR2^Cd19/Cd19 mice were stained with cell proliferation dye and stimulated with (A) polyclonal anti-IgM F(ab′)₂ fragments; (B) anti-IgM F(ab′)₂, and anti-CD40 Ab; (C) CpG or (D) anti-CD40 Ab. B cell proliferative response was analyzed by flow cytometry 2 (CpG) or 3 (all other conditions) days after stimulation. Gates in histograms and adjacent numbers indicate the frequency of divided cells. (E) Frequency of IgG⁺ class switched B cells was measured within divided cells. FACS plots and adjacent chart are representative of two (CpG) or three independent experiments. Bars represent SD. Statistical analysis was performed using two-way ANOVA (p-values for effect of genotype).