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. 2019 Mar 18;10:485. doi: 10.3389/fimmu.2019.00485

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Copyright © 2019 Díaz-Delgado, Groch, Ressio, Riskallah, Sierra, Sacchini, Quesada-Canales, Arbelo, Fernàndez, Santos-Neto, Ikeda, Carvalho, Azevedo, Lailson-Brito, Flach, Kanamura, Fernandes, Cogliati, Centelleghe, Mazzariol, Di Renzo, Di Francesco, Di Guardo and Catão-Dias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Caspase 3 (CAS3) immunohistochemical findings. (A) Lymph node (case 22). Increased expression of CAS3 throughout the cortex. 100×. Inset: lymph node (case 22). Detail of increased CAS3 expression in mononuclear cells (MNCs) of mantle and paracortex. 400×. (B) Spleen (case 21). Increased expression of CAS3 throughout the white and red pulp. 100×. Inset: spleen (case 21). Detail of increased expression of CAS3 in white and red pulp. 400×. (C) Lung (case 18). Increased expression of CAS3 in proliferative and necrotizing bronchiolitis. 100×. Inset: lung (case 21). Detail of CAS3+ circulating MNCs in alveolar capillaries. 200×. (D) Cerebrum (case 24). Increased CAS3 expression in inflammatory cell infiltrates in Virchow-Robins space and adjacent neuroparenchyma. 400×. Inset: cerebrum (case 26). Detail of CAS3⁺ neurons, neuroglia, and infiltrating MNCs. 400×.