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. 2019 Mar 18;10:485. doi: 10.3389/fimmu.2019.00485

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Copyright © 2019 Díaz-Delgado, Groch, Ressio, Riskallah, Sierra, Sacchini, Quesada-Canales, Arbelo, Fernàndez, Santos-Neto, Ikeda, Carvalho, Azevedo, Lailson-Brito, Flach, Kanamura, Fernandes, Cogliati, Centelleghe, Mazzariol, Di Renzo, Di Francesco, Di Guardo and Catão-Dias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Interferon (IFN)-γ immunohistochemical findings. (A) Lymph node (case 17). Scattered MNCs including lymphocytes and histiocytes express IFNγ in cortex, paracortex and subcapsular/marginal sinus (square). Right inset: lymph node (case 17). IFNγ-expressing histiocyte within subcapsular/marginal sinus. 400×. Left inset: lymph node (case 17). Moderate number of IFNγ-expressing histiocytes and lymphocytes within paracortical/medullary sinuses. (B) Spleen (case 22). Scattered IFNγ-expressing cells in white and red pulp. Detail of IFNγ-expressing cells. 100×. Inset: 22. 400×. (C) Lung (case 23). IFNγ-expressing cells mainly include alveolar macrophages and scattered interstitial mononuclear cells. 100×. Inset: lung (case 23). Detail of IFNγ-expressing cells within perialveolar lymphocytic aggregate and rare alveolar macrophage. 400×. (D) Cerebrum (case 9). Meningeal and neuroparenchymal IFNγ-expressing cells. 400×.