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. 2019 Mar 18;10:485. doi: 10.3389/fimmu.2019.00485

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Copyright © 2019 Díaz-Delgado, Groch, Ressio, Riskallah, Sierra, Sacchini, Quesada-Canales, Arbelo, Fernàndez, Santos-Neto, Ikeda, Carvalho, Azevedo, Lailson-Brito, Flach, Kanamura, Fernandes, Cogliati, Centelleghe, Mazzariol, Di Renzo, Di Francesco, Di Guardo and Catão-Dias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Paired box protein (PAX)-5 immunohistochemical findings. (A) Lymph node (case 17). Mild to moderate PAX5⁺ lymphocyte depletion in cortical area. 100×. Left inset: lymph node (case 17). Detail of mild PAX5⁺ lymphocyte depletion in follicle. 400×. Right inset: lymph node (case 18). PAX5⁺ lymphocyte hyperplasia in medullary cord. 400×. (B) Spleen (case 17). Mild PAX5⁺ lymphocyte follicular depletion. 200×. (C) Lung (case 18). Increased numbers of PAX5⁺ lymphocytes in lung interstitium. 400×. (D) Cerebrum (case 13). Moderate infiltration of PAX5 lymphocytes in leptomeninges. 200×. Inset: cerebrum (case 13). Detail of leptomeningeal infiltrating PAX5⁺ lymphocytes. 400×.