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. 2019 Mar 18;10:485. doi: 10.3389/fimmu.2019.00485

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Copyright © 2019 Díaz-Delgado, Groch, Ressio, Riskallah, Sierra, Sacchini, Quesada-Canales, Arbelo, Fernàndez, Santos-Neto, Ikeda, Carvalho, Azevedo, Lailson-Brito, Flach, Kanamura, Fernandes, Cogliati, Centelleghe, Mazzariol, Di Renzo, Di Francesco, Di Guardo and Catão-Dias.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lysozyme immunohistochemical findings. (A) Lymph node (case 25). Lysozyme⁺ histiocytic cells in cortical and paracortical area. 200×. Inset: lymph node (case 25). Abundant intrasinus lysozyme-expressing histiocytes. 200×. (B) Spleen (case 14). Lysozyme⁺ histiocytes through the red pulp. 40×. Inset: spleen (case 14). Detail of lysozyme histiocytes in red pulp. 400×. (C) Lung (case 11). Overexpression of lysozyme by inflammatory cells and exudate in inflamed bronchioles and alveoli associated with CeMV and concomitant verminous pneumonia. 40×. Upper inset: lung (case 13). Circulating MNCs (including presumed pulmonary intravascular macrophages) are lysozyme⁺. 400×. Lower inset: lung (case 21). Increased lysozyme+ (mainly histiocytes) cells within inflammatory focus. 400×. (D) Spinal cord (case 13). Moderate number of lysozyme+ histiocytes in spinal cord leptomeninges. 100×. Inset: spinal cord (case 13). Detail of lysozyme+ histiocytic meningeal infiltrate. 400×.