Table 4.

Summary of results for selected immunomarkers in lung of Guiana dolphins (Sotalia guianensis), striped dolphins (Stenella coeruleoalba), and bottlenose dolphins (Tursiops truncatus) included in this study.

No	CAS3	CD3	CD20	CD57	CD68	FoxP3	HLA-DRα	Iba1	IFNγ	IgG	IL4	IL10	Lysozyme	TGFβ	PAX-5
1	+/2	+/2	+/3	–/0	+/2	–/0	+/3	+/3	+/2	+,++/3	+/3	+/2	+/3	+/2	+/2
2	+/2	+/3	+/3	+/3	+/3	–/0	+/3	+/3	+/3	+,++/3	+/3	+/2	+/3	+/2	+/2
3a	++/2	+/3	+/3	–/0	++/2	+/2	+,++/3	+/3	+,++/2	+,++/3	+/3	+,++/2	++,+++/3	+/2	+/2
4	+/2	+/3	+/3	–/0	++/2	–/0	+/3	+/3	++/3	+/3	+/3	+/2	+/3	+/2	+/2
5	+/3	+/3	+/3	–/0	+/2	+/2	+/3	++/3	+/3	+/2	+/2	+,++/2	++/3	+/2	+/3
6	+/2	+/2	+/3	+/3	+/3	–/0	+/3	+/2	+/2	+/3	+/2	+/2	+/3	+/2	+/2
7	+/2	+/3	+/3	+/2	+/3	+/2	+/3	+/2	+/3	+/2	+/2	+/2	+/3	+/2	+/2
8	+/2	+/3	+/3	–/0	+/3	+/3	+/2	+/3	+/3	+,++/3	+/2	+/2	+,++/3	+/2	+/2
9	++/3	++,+++/3	+/3	–/0	+/3	+/3	++/3	++/3	+/2	+,++/3	+,++/2	+,++/2	+/3	+/2	+/2
10	++/2	+/3	+/3	–/0	+/3	+/3	+/3	+/3	+/2	+/3	+/2	+/2	++/3	+/2	+/2
11b	++/2	+/2	+/3	–/0	+/2	+/2	+/3	++/3	+/3	+/3	+,++/2	++,+++/3	++,+++/3	+/2	+/2
12	+/3	+/3	+,++/3	+/3	++/3	+/3	+,+++/3	++/3	+/3	++/3	+/3	+,++/3	+/3	+/3	+/3
13c	++/3	+/2	+,++/3	–/0	++/3	+/2	+,++/3	++/3	+/3	+/3	+/3	++,+++/3	++,+++/3		++/2
14	++/3	+/2	+/2	–/0	+/3	+/2	+/3	+,++/3	+/3	+/2	+/2	+/3	+/3	+/2	+/2
15	+/3	+/3	+,++/3	+/3	+/3	+/3	++/3	+,++/3	+,++/3	+,++/3	+/3	++,+++/3	++/2	+/2	+/3
16	++/3	++/3	+/3	–/0	+/3	+/2	+/3	+,++/3	+/3	+/2	+/2	+/2	+/3	+/2	+/3
17	++/3	++/3	++/3	+/2	+/3	+/3	+,++/3	+,++/3	+,++/3	+/3	+/3	+,++/2	+,++/2	+/3	+/2
18	++/3	++/3	++/3	+/3	++/3	+/3	++,+++/3	++/3	+/3	++/3	+/2	+,++/3	++/3	+/2	+,++/3
19	+++/3	++/3	+,++/2	+/2	+/2	+/3	+,++/3	++++/3	+++/3	++/3	+,++/3	++,+++/2	+,++/3	+/3	+/2
20	+/3	+/2	+/3	–/0	+/2	+/3	+/3	+,++/3	+/3	+/3	+/3	+/3	+,++/3	–/0	+/2
21	+/3	+/3	+/3	+/2	+/2	+/2	+/3	+/3	+/3	+/3	+/2	+/3	+,++/3	+/2	+/2
22	++/3	+,++/3	+/3	+/2	+/2	+/2	+,+++/3	+/3	+/2	+/2	+,++/2	+/2	+/3	+/2	+/3
23	+/2	+/3	+/3	+/2	+/3	+/2	+,++/3	+/3	+,++/3	+/3	+/2	+/3	+/3	+/2	+/2
24	+/3	+/3	+/3	–/0	+/3	+/2	+/3	+/3	+/2	+/3	+/3	+/3	+/3	+/2	+/2
25d	++/3	++++/3	++,+++/3	+/3	++,+++/3	+/3	+,++/3	+/3	+/3	+,++/3	++,+++/2	+/3	++,+++/3	+/2	+,++/3
26	+/3	+/3	+/3	NE	NE	NE	NE	+/3	+/3	+/3	NE	NE	NE	NE	NE
27e	+/3	+/2	+/3	–/0	+,++/3	+/2	+/2	+/2	+/2	+/3	+/2	+/2	+,++/3	+/2	+/2
28	+/3	+/3	+/3	–/0	–/0	–/0	+/3	+/3	–/0	–/0	+/2	+/2	–/0	–/0	+/3
29	+/3	+/3	+/3	–/0	–/0	–/0	+/3	+/3	+/3	+/2	+/2	+,++/2	–/0	+/3	+/3
30	+/3	+/3	+/3	–/0	–/0	–/0	+/3	+/3	–/0	+/2	+/2	+/2	+/2	+/2	+/3

CD, cluster of differentiation; FoxP3, Forkhead Box P3; HLA, human leukocyte antigen (synonym major histocompatibility complex); IFN, interferon; Ig, immunoglobulin; IL, interleukin; TGF, transforming growth factor; Pax-5, paired box 5; NE, not evaluated. Semiquantitative analysis of immunopositive cells: –, no; +, <10%; ++, 10–50%; +++, 50–90%, and ++++, >90% immunopositive cells. Subjective labeling intensity score of immunopositive cells: 0, 1, 2, and 3.

^aMultisystemic hyphate mycosis (lung, kidney).

^bHyphate mycosis (lung).

^cSuspect Brucella coinfection (primarily CNS lesions).

^dSepsis by Staphylococcus aureus (particularly severe CNS and lung lesions).

^eMultisystemic hyphate mycosis (lung, cerebrum).