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. 2019 Mar 18;10:485. doi: 10.3389/fimmu.2019.00485

Table 5.

Summary of results for selected immunomarkers in cerebrum, cerebellum, brain stem, and spinal cord of Guiana dolphins (Sotalia guianensis), striped dolphins (Stenella coeruleoalba), and bottlenose dolphins (Tursiops truncatus) included in this study.

No CAS3 CD3 CD20 CD57 CD68 FoxP3 HLA-DRα Iba1 IFNγ IgG IL4 IL10 Lysozyme TGFβ PAX-5
1 +/2 –/0 –/0 –/0 –/0 –/0 +/3 –/0 +/3 –/0 –/0 –/0 +/3 –/0 –/0
2 +/2 –/0 –/0 –/0 –/0 –/0 +/3 +/2 –/0 –/0 –/0 –/0 +/3 –/0 –/0
3a +/3 –/0 –/0 –/0 –/0 –/0 +/3 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0
4 –/0 –/0 –/0 –/0 –/0 –/0 +/3 +/2 –/0 –/0 +/2 –/0 –/0 –/0 –/0
5 –/0 –/0 –/0 –/0 –/0 –/0 +/3 –/0 –/0 –/0 –/0 –/0 +/3 –/0 –/0
6 +/2 –/0 –/0 –/0 +/2 –/0 +/3 +/3 –/0 –/0 –/0 –/0 +/3 –/0 –/0
7 +/3 +/3 –/0 –/0 –/0 –/0 +/3 –/0 +/3 –/0 +/2 –/0 +/2 –/0 –/0
8 +/3 –/0 –/0 –/0 –/0 –/0 +/3 –/0 –/0 –/0 –/0 –/0 +/3 –/0 –/0
9 +/2 +/3 –/0 –/0 –/0 –/0 +/3 +/3 +/3 +/2 –/0 –/0 +/3 –/0 –/0
10 +/3 +/3 –/0 –/0 +/2 –/0 +/3 +/3 +/3 –/0 +/2 –/0 +/3 –/0 –/0
11b +/2 –/0 –/0 –/0 +/2 –/0 +/3 +/3 –/0 –/0 –/0 –/0 +/3 –/0 –/0
12 +/3 ++/2 +/2 –/0 +/2 –/0 +/2 +/3 +/3 +/3 –/0 +/2 +/3 –/0 +/2
13c +/3 ++/2 ++,+++/3 +/3 +/2 +/3 +++/3 ++,+++/3 ++/3 ++/3 +/2 –/0 +,++/3 –/0 ++/3
14 +/3 ++/2 +,++/2 –/0 +/2 +/2 ++/3 +/3 +/3 +/3 +/2 +/3 +/3 –/0 +/2
15 +/2 +/3 +/3 –/0 +/2 –/0 ++/3 +/3 +/3 +/3 +/2 –/0 +/2 –/0 +/2
16 +/2 ++/2 +/2 –/0 +/2 –/0 ++/3 +/3 +/2 +/2 +/2 –/0 +/3 –/0 +/2
17 +/2 ++/3 +/2 –/0 +/2 –/0 ++/3 +/3 +/3 +/3 +/3 –/0 +/3 –/0 +/2
18 +/2 ++/3 +,++/3 –/0 +/2 –/0 ++/3 +,++/3 +/2 +/3 +/3 –/0 +/3 –/0 +/2
19 ++/3 ++/3 +,++/3 –/0 +/2 –/0 +++/3 ++/3 +/3 +/2 +/3 +/2 +/3 –/0 +/2
20 +/2 +/2 +/2 –/0 –/0 –/0 +/3 +/2 +/2 +/2 +/3 –/0 +/2 –/0 –/0
21 +/2 +/3 +/2 –/0 +/3 –/0 +/2 +/3 +,++/3 –/0 +/2 –/0 +/3 –/0 –/0
22 +/2 +/3 +/3 –/0 +/2 –/0 +/2 +/3 +/3 +/3 –/0 –/0 +/2 +/2 +/2
23 +/3 +/3 +/3 –/0 +/2 –/0 +/3 +/2 +/3 +/2 +/2 –/0 +/3 –/0 –/0
24 +,++/3 +++/3 +/3 –/0 +/3 –/0 +,+++/3 +/2 +/3 +/2 +/2 –/0 +/3 –/0 +/2
25d +,++/2 +,+++/3 ++/3 +/3 +/3 –/0 ++/3 +,+++/3 +/3 +,++/3 +/2 +/3 +,+++/3 +/3 +/2
26 ++/3 +++/3 +/3 +/3 +/2 –/0 +,++/3 ++/3 +,++/2 +/3 +/2 –/0 +/3 –/0 +/2
27e ++/3 +/3 +/2 –/0 +/2 –/0 +/3 +/2 –/0 +/3 +/3 –/0 +,++/3 –/0 –/0
28 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0
29 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0
30 +/3 –/0 –/0 –/0 –/0 –/0 +/2 –/0 –/0 –/0 –/0 –/0 –/0 –/0 –/0

CD, cluster of differentiation; FoxP3, Forkhead Box P3; HLA, human leukocyte antigen (synonym major histocompatibility complex); IFN, interferon; Ig, immunoglobulin; IL, interleukin; TGF, transforming growth factor; Pax-5, paired box 5; NE, not evaluated. Semiquantitative analysis of immunopositive cells: –, no; +, <10%; ++, 10–50%; +++, 50–90%, and ++++, >90% immunopositive cells. Subjective labeling intensity score of immunopositive cells: 0, 1, 2, and 3.

a

Multisystemic hyphate mycosis (lung, kidney).

b

Hyphate mycosis (lung).

c

Suspect Brucella coinfection (primarily CNS lesions).

d

Sepsis by Staphylococcus aureus (particularly severe CNS and lung lesions).

e

Multisystemic hyphate mycosis (lung, cerebrum).